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Literature summary extracted from

  • Randles, D.
    Temperature dependence of dihydropteridine reductase activity (1986), Eur. J. Biochem., 155, 301-304.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.34 0.0008
-
 quinonoid 7,8-(6H)-dihydrobiopterin at 20°C Homo sapiens
1.5.1.34 0.0015
-
 quinonoid 7,8-(6H)-dihydrobiopterin at 25°C Homo sapiens
1.5.1.34 0.0024
-
 quinonoid 7,8-(6H)-dihydrobiopterin at 30°C Homo sapiens
1.5.1.34 0.0063
-
 quinonoid 7,8-(6H)-dihydrobiopterin at 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.34 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.5.1.34 a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+ ordered bi-bi mechanism, binding of NADH first and dissociation of NAD+ last Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.34 quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
-
 Homo sapiens 5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
 ?
1.5.1.34 quinonoid 7,8-(6H)-dihydropterin + NADPH + H+
-
 Homo sapiens 5,6,7,8-tetrahydropterin + NADP+
-
 r

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.5.1.34 10.9
-
 quinonoid 7,8-(6H)-dihydrobiopterin at 20°C Homo sapiens
1.5.1.34 10.9
-
 quinonoid 7,8-(6H)-dihydropterin at 20°C Homo sapiens
1.5.1.34 23.7
-
 quinonoid 7,8-(6H)-dihydrobiopterin at 25°C Homo sapiens
1.5.1.34 23.7
-
 quinonoid 7,8-(6H)-dihydropterin at 25°C Homo sapiens
1.5.1.34 28.9
-
 quinonoid 7,8-(6H)-dihydropterin 30°C Homo sapiens
1.5.1.34 28.9
-
 quinonoid 7,8-(6H)-dihydrobiopterin at 30°C Homo sapiens
1.5.1.34 113
-
 quinonoid 7,8-(6H)-dihydrobiopterin at 37°C Homo sapiens
1.5.1.34 113
-
 quinonoid 7,8-(6H)-dihydropterin at 37°C Homo sapiens